|
KMID : 0388220100170020143
|
|
Journal of the Korean Rheumatism Association
2010 Volume.17 No. 2 p.143 ~ p.152
|
|
|
Clinicial Significance of Spontaneous Pneumomediastinum in Dermatomyositis/Polymyositis
|
|
Kim Jin-Ju
Kim Dam
Kim Eun-Kyoung
Sohn Il-Woong
Jung Kyoung-Hee
Choi Chan-Bum
Sung Yoon-Kyoung
Jun Jae-Bum
Uhm Wan-Sik
Kim Tae-Hwan
Bae Sang-Chul
Yoo Dae-Hyun
|
|
|
Abstract
|
|
|
Objective: Pneumomediastinum (PnM), a rare complication of dermatomyositis and polymyositis (DM/PM), is sporadic and has an unclear pathogenesis. PnM is almost always associated with interstitial lung disease (ILD), and is a poor prognostic factor in inflammatory myositis patients. We studied the prevalence of PnM in Korean DM/PM and its clinical significance.
Methods: We retrospectively studied the medical records of 161 patients diagnosed with DM/PM meeting Bohan-Peter’s criteria at Hanyang University Hospital for Rheumatic Diseases from 1995 to 2010. We collected following findings; demographic data, diagnosis, lung involvement, cause of death, and duration from diagnosis to death.
Results: One hundred nineteen patients (73.9%) were DM and 42 patients (26.1%) were PM. Eighty three patients (51.6%) developed ILD at diagnosis or during follow up. Eighteen patients (11.2%) died because of ILD aggravation, infection, or malignancy. The mean duration from diagnosis to death was 11.5 months, with 10 patients (6.2%) dying from from ILD aggravation but none with spontaneous PnM. 6 patients (3.7%) presented with PnM, and it was associated with ILD worsening in all cases. PnM resolved with O2 inhalation, corticosteroids, and/or immunosuppressive agents after 11 weeks (mean) of therapy
Conclusion: PnM is rare but associates with DM and aggravation of ILD. PnM does not usually cause fatalities and can be cured by appropriate therapy.
|
|
|
KEYWORD
|
|
|
Pneumomediastinum, Dermatomyositis/polymyositis, Interstitial lung disease, Prognosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|
|